The brutal hunt for purebloods continues as the ultimate vampire hunter Blade battles to defeat his immortal ennemies in this feature-length premiere of the hit TV series. The House of Chthon, an ancient evil sect of vampires, is growing stronger everyday. Led by the vampire overlord Marcus, their objective is to create a vaccine that will give rise to a new breed of and save humanity before super vampires, immune to vampire weaknesses. In order to stop them, Blade joins forces with the ruthless and beautiful Krista Starr whose brother was slain by the vampires and who will go to incredible lengths to infiltrate the House of Chthon. With her help, Blade will do everything he can to win this war before it's too late.